Idogen´s technology

There are many situations where the body’s immune system can cause damage instead of protecting us. One example is when it causes transplant rejection. Another is when the immune system neutralizes the activity of biological drugs, for example, in the treatment of hemophilia with factor VIII. Yet another situation is in the case of various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases, type 1 diabetes and multiple sclerosis (MS), where the immune system attacks the body’s own proteins or antigens.

The ability to produce new treatments that maintain a properly functioning immune system, meaning one that protects and defends the body from invasion by foreign organisms – such as viruses, bacteria and tumors – would revolutionize life for patients with severe chronic illnesses. Idogen wants to be part of this revolution by developing
new cell therapies – a type of treatment that differs from conventional medical therapies. Instead of administering a chemical substance to the body, the patient is treated with their own cells, which first obtain their unique tolerogenic profile outside the body before being returned to the patient.

Idogen’s treatment is based on dendritic cells – a type of white blood cell – that plays a central role in the immune system because they control other immune system cells’ recognition of what belongs in the body (self) and what is foreign (non-self). When we are exposed to bacteria or viruses, the dendritic cells trigger our immune response. At the same time, they ensure that the immune system does not attack our own body. The dendritic cells that prevent the immune system from attacking the body’s own, healthy cells are called tolerogenic. The aim of Idogen’s technology is to develop tolerogenic dendritic cells that are programmed to tolerate the immune system to defined molecules or antigens.

Idogen´s technology and treatment method

Dendritic cells control other immune system cells’ recognition of, and reaction to, what belongs in the body and what is foreign. The dendritic cells that recognise bacteria or viruses activate our immune system (red) and those that recognize the body’s own cells stop the body from attacking its own tissues and induce tolerance (green). The goal of Idogen’s cell therapy is to teach the immune system so as to counteract undesirable activation while leaving the rest of the immune system unaffected.

Idogen’s therapy entails treating cells from the patient’s blood outside the body for development into tolerogenic dendritic cells. These programmed dendritic cells are then returned to the patient as a cell therapy in order to specifically counteract a harmful immune response and induce tolerance, without affecting the normal functions of the immune system.