Research overview

Idogen´s technology aims at developing tolerant dendritic cells that are programmed for defined molecules, also called antigens. Idogen´s treatment method can be adapted to various diseases through small changes. In autoimmune diseases, the body’s immune system fights self-antigens, which could be avoided by reprogramming the immune system with Idogen´s technology. To prevent rejection after organ transplantation is another field.

Idogen has demonstrated the technology´s potential in several proof-of-concept studies. Idogen has successfully managed to demonstrate in an animal model of Hemophilia A that treatment with tolerogenicdendritic cells results in a decreased incidence of inhibitory factor VIII antibodies and that the treatment has a long-term effect. Idogen has also shown “proof-of-principle” in transplantation by preventing rejection of insulin producing cells in animals with diabetes and in a model for rheumatoid arthritis, by delaying disease progression.

Proof-of-concept in a haemophilia A model

In 2015, Idogen initiated a ”proof-of-concept” study of the company’s cell therapy in an animal model of hemophilia A with human factor VIII. The study results showed that treatment with tolerogenic dendritic cells results in reduced formation of factor VIII inhibitory antibodies and treatment has a prolonged effect. If the method can be transferred to humans it means that treatment with tolerogenic cell therapy provides protection against the formation of inhibitory antibodies in patients with hemophilia A.

Idogen’s tolerogenic cell therapy reduces the presence of inhibitory factor VIII antibodies in the model of hemophilia